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2016-5-20 · CHF-6001 is in phase II clinical trials by Chiesi Farmaceutici for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
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The study will be conducted in a single centre and will consist of a single dose part and a multiple dose part. Seven single doses of CHF 6001 will be administered according to an escalation, alternate cross over scheme. Five multiple doses of CHF 6001 will be administered for 7 days according to a sequential escalation scheme. CHF 6001 shows sub-nanomolar po tency in inhibiting the relea se of the clinically relevant pro -inflammatory cytokine TNF- α fro m PBMCs stimulated with LPS. The combination of CHF-6001 and tiotropium or glycopyrrolate, in concentrations partially effective by themselves, fully inhibited methacholine-induced remodeling in combination.
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The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices. Am J Physiol Lung Cell Mol Physiol 1 september 2017.
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